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Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association



Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association



Biochemical and Biophysical Research Communications 327(1): 49-56



The nuclease hypersensitive element NHE III1 is an important anti-cancer target as the transcription of oncogene c-myc is largely regulated by it. It has been postulated that regulatory control is mediated by G-quadruplex formation in the NHE anti-sense strand through a competition between the duplex and the quadruplex states. A mutation in the NHE has been implicated in cancer.

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Accession: 012471812

Download citation: RISBibTeXText

PMID: 15629428

DOI: 10.1016/j.bbrc.2004.11.137


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