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Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

Journal of Biological Chemistry 279(48): 50295-50301

Omi/HtrA2 is a nuclear-encoded mitochondrial serine protease that has a pro-apoptotic function in mammalian cells. Upon induction of apoptosis, Omi translocates to the cytoplasm and participates in caspase-dependent apoptosis by binding and degrading inhibitor of apoptosis proteins. Omi can also initiate caspase-independent apoptosis in a process that relies entirely on its ability to function as an active protease.

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Accession: 012496618

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PMID: 15371414

DOI: 10.1074/jbc.m406006200

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