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Regulation of bone sialoprotein (BSP) gene transcription by lipopolysaccharide



Regulation of bone sialoprotein (BSP) gene transcription by lipopolysaccharide



Journal of Cellular Biochemistry 97(2): 368-379



Lipopolysaccharide (LPS) is a major mediator of inflammatory responses in periodontal disease that inhibits bone formation and stimulates bone resorption. To determine the molecular mechanisms involved in the suppression of bone formation, we have analyzed the effects of LPS on BSP gene expression. Bone sialoprotein (BSP) is a mineralized tissue-specific protein that appears to function in the initial mineralization of bone.

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Accession: 012497208

Download citation: RISBibTeXText

PMID: 16187297

DOI: 10.1002/jcb.20628


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