Section 13
Chapter 12,500

Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)

Shimojo, M.; Hersh, L.B.

Life Sciences 74(18): 2213-2225


ISSN/ISBN: 0024-3205
PMID: 15017977
DOI: 10.1016/j.lfs.2003.08.045
Accession: 012499007

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The cholinergic gene locus is comprised of two genes, the choline acetyltransferase gene and the vesicular acetylcholine transporter gene. The vesicular acetylcholine transporter gene is located within the first intron of the choline acetyltransferase gene. This arrangement permits coordinate regulation of the locus. Protein kinase A regulates expression of the cholinergic gene locus in PC12 cells.

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