Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF)
Shimojo, M.; Hersh, L.B.
Life Sciences 74(18): 2213-2225
2004
ISSN/ISBN: 0024-3205 PMID: 15017977 DOI: 10.1016/j.lfs.2003.08.045
Accession: 012499007
The cholinergic gene locus is comprised of two genes, the choline acetyltransferase gene and the vesicular acetylcholine transporter gene. The vesicular acetylcholine transporter gene is located within the first intron of the choline acetyltransferase gene. This arrangement permits coordinate regulation of the locus. Protein kinase A regulates expression of the cholinergic gene locus in PC12 cells.
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