+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Regulatory T-lymphocytes in asthma



Regulatory T-lymphocytes in asthma



European Respiratory Journal 26(5): 918-932



T-helper cell type (Th)2 lymphocytes play an important role in the initiation, progression and persistence of allergic diseases, including asthma. However, little is known about immunoregulatory mechanisms that determine susceptibility to, severity of, or persistence of asthma. The concept of a disturbed Th1/Th2 balance, although having furthered the present understanding of immunoregulation in asthma, has recently been named a "procrustean paradigm", because of its failure to adequately explain many (pre)clinical observations. In recent years, the general knowledge regarding the regulation of infectious, autoimmune diseases, asthma and allergen immunotherapy by T-regulatory (Treg) cells, has rapidly increased. Many different Treg subsets have been described, including CD8+ Treg cells, natural killer (NK) cells and several different CD4+ Treg cell subsets. In this review, the authors will focus on two major and well-described CD4+ Treg cell subsets. These consist of naturally occurring CD25+ Treg cells and adaptive Treg cells that are postulated to prevent immune responses against self-antigens and adaptive immune responses, respectively. The adaptive T-regulatory cells are further subdivided into T-regulatory cells type 1 and T-helper cell type 3 that mediate suppression exclusively via the cytokines interleukin-10 and transforming growth factor-beta, respectively.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012499531

Download citation: RISBibTeXText

PMID: 16264056

DOI: 10.1183/09031936.05.00011205


Related references

The role of regulatory T lymphocytes in asthma. Zhonghua Jie he He Hu Xi Za Zhi 28(12): 856-858, 2005

CD4CD25 regulatory T lymphocytes in allergy and asthma. Allergy 60(8): 986-995, 2005

The role of regulatory T lymphocytes in asthma pathogenesis. Current Allergy and Asthma Reports 5(2): 136-141, 2005

T regulatory lymphocytes, atopy and asthma: a new concept in three dimensions. Revue des Maladies Respiratoires 22(2 Pt 1): 305-311, 2005

Role of Foxp3 and regulatory CD4+CD25+ T-lymphocytes in bronchial asthma. Egyptian Journal of Immunology 15(2): 113-123, 2010

Aberrant Expression of Novel Cytokine IL-38 and Regulatory T Lymphocytes in Childhood Asthma. Molecules 21(7):, 2016

Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma. Clinical Immunology 113(2): 172-178, 2004

Leukocyte migration inhibition test as a model for studying the regulatory lymphocytes study of the regulatory action of t lymphocytes in rheumatoid arthritis. Immunologiya (2): 53-56, 1985

The role of lymphocytes in bronchial asthma 1. surface properties of lymphocytes in bronchoalveolar lavage fluid of bronchial asthma patients. Okayama Igakkai Zasshi 97(1-2): 65-78, 1985

The significance of cell cycle distribution and expression of cell cycle regulatory proteins in T lymphocytes in patients with acute asthma attack. Zhonghua Jie He He Hu Xi Za Zhi 27(9): 601-603, 2004

Regulatory T cells in HBV and HCV liver diseases: implication of regulatory T lymphocytes in the control of immune response. Expert Opinion on Biological Therapy 10(11): 1563-1572, 2010

Regulatory T-cells and hepatocellular carcinoma: implication of the regulatory T lymphocytes in the control of the immune response. Bulletin du Cancer 95(12): 1219-1225, 2008

Regulatory effect and distribution of lymphocytes in synovial tissue of RA patients: Restricted access of regulatory T-cells?. 2006

Induction of the regulatory ligand PD-L2 on dendritic cells and the co-regulatory receptor PD-1 on CD4 T lymphocytes during early experimental schistosomiasis. American Journal of Tropical Medicine & Hygiene 69(3 Suppl.): 200, 2003

The 4b4 and 2h4 subsets of cd4 lymphocytes manifest distinct regulatory roles in the development of cytotoxic t lymphocytes. Clinical Research 35(3): 457A, 1987