+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects



Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects



American Journal of Cardiology 95(5): 655-657



We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC >/=100, and CAC >/=75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of >/=2 metabolic RFs, magnifying the risks for those exposed to both.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012500679

Download citation: RISBibTeXText

PMID: 15721113

DOI: 10.1016/j.amjcard.2004.10.045


Related references

Arterial reactivity is impaired in young healthy subjects with a family history of premature coronary heart disease independent of other coronary risk factors. Circulation 90(4 PART 2): I363, 1994

Association of traditional risk factors with coronary calcification in persons with a family history of premature coronary heart disease: the study of the inherited risk of coronary atherosclerosis. Journal of Investigative Medicine 49(4): 353-361, 2001

Association of traditional risk factors with coronary artery calcification in persons with a family history of premature coronary heart disease The study of the inherited risk of coronary atherosclerosis. Circulation 102(18 Supplement): II 835, October 31, 2000

A synergistic interaction between premature family history of coronary heart disease and metabolic risk factors enhances risk of subclinical atherosclerosis. Journal of the American College of Cardiology 43(5 Supplement A): 453A-454A, March 3, 2004

Relation of coronary vasoreactivity and coronary calcification in asymptomatic subjects with a family history of premature coronary artery disease. European Journal of Nuclear Medicine and Molecular Imaging 31(5): 663-670, 2004

Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass. Cardiology in the Young 24(5): 938-940, 2015

Coronary calcification assessed by MDCT in asymptomatic subjects with family history of premature coronary heart disease. Canadian Journal of Cardiology 23(Suppl. C): 183C, 2007

Young adults with family history of coronary heart disease have increased arterial vulnerability to metabolic risk factors: the Cardiovascular Risk in Young Finns Study. Arteriosclerosis, Thrombosis, and Vascular Biology 26(6): 1376-1382, 2006

The association of coronary calcium score and conventional cardiovascular risk factors in Type 2 diabetic subjects asymptomatic for coronary heart disease (The PREDICT Study). Diabetic Medicine 21(10): 1129-1134, 2004

Coronary Artery Calcium Improves Risk Assessment in Adults With a Family History of Premature Coronary Heart Disease: Results From Multiethnic Study of Atherosclerosis. Circulation. Cardiovascular Imaging 8(6): E003186, 2015

Family history of premature coronary heart disease is associated with higher coronary artery calcium burden in asymptomatic individuals. Journal of the American College of Cardiology 41(6 Supplement A): 457A, March 19, 2003

Coronary risk factors in school children in relation to their family history of coronary heart disease and hyperlipidemia. Acta Paediatrica Japonica. 40(1): 30-34,., 1998

A common variant of the eNOS gene predicts future coronary disease events independently from coronary risk factors in asymptomatic siblings of patients with premature coronary heart disease. Circulation 108(17 Supplement): IV-771, October 28, 2003

Prevalence of emerging cardiovascular risk factors in younger individuals with a family history of premature coronary heart disease and low Framingham risk score. Clinical Cardiology 31(11): 542-545, 2008

Coronary artery calcium findings in asymptomatic subjects with family history of premature coronary artery disease. Bmc Cardiovascular Disorders 12: 53, 2013