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Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine (1A) receptor agonist

Piper, B.J.; Vu, H.L.; Safain, M.G.; Oliver, A.J.; Meyer, J.S.

Journal of Pharmacology and Experimental Therapeutics 317(2): 838-849

2006

ISSN/ISBN: 0022-3565
PMID: 16434566
DOI: 10.1124/jpet.105.095760
Accession: 012507244
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Adolescent users of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) may escalate their dose because of the development of tolerance. We examined the influence of intermittent adolescent MDMA exposure on the behavioral, physiological, and neurochemical responses to a subsequent MDMA "binge" or to a 5-hydroxytryptamine(1A) (5-HT1A) receptor challenge. Male Sprague-Dawley rats were given MDMA (10 mg/kg b.i.d.) or saline every 5th day on postnatal days (PDs) 35 to 60.

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