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Role of tissue factor in thrombosis. Coagulation-inflammation- thrombosis circuit

Role of tissue factor in thrombosis. Coagulation-inflammation- thrombosis circuit

Frontiers in Bioscience 11: 256-271

Tissue factor ( TF) plays a role in thrombogenesis. TF initiates blood coagulation resulting in the generation of protease coagulant mediators ( FVIIa, FXa, and FIIa) and fibrin production. TF hypercoagulablility directly contributes to thrombus formation resulting from the major events of fibrin deposition and FIIa- induced platelet activation/ aggregation.

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Accession: 012528004

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DOI: 10.2741/1796

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