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Screening of botulinum neurotoxin type A-binding peptides by phage display peptide library



Screening of botulinum neurotoxin type A-binding peptides by phage display peptide library



Wei Sheng Wu Xue Bao 46(1): 136-138



To seek effective inhibitor against BoNT/A, in this study, BoNT/A-binding peptides were screened from phage display peptide library using synthesized and identified mimicry peptides that contained antigenic epitopes as targets. According to the homology of the amino acid sequences of displayed peptides, most had same motifs respectively. ELISA assay confirmed that identified positive clones respectively against P4 and P5 could specifically bind BoNT/A.

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Accession: 012536902

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PMID: 16579481


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