Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis

Kirkpatrick, W.R.; Coco, B.J.; Patterson, T.F.

Antimicrobial Agents and ChemoTherapy 50(4): 1567-1569


ISSN/ISBN: 0066-4804
PMID: 16569887
DOI: 10.1128/aac.50.4.1567-1569.2006
Accession: 012547606

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We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.