+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Social instability in female rats: the relationship between stress-related and anxiety-like consequences



Social instability in female rats: the relationship between stress-related and anxiety-like consequences



Physiology and Behavior 84(4): 511-518



It is generally believed that anxiety and depression develop in response to stressful events that chronically increase glucocorticoid production (which in turn affects various neurotransmitter systems). In contrast to depression, however, the relationship between chronic stress and anxiety is less clear, as anxiety patients often show normal glucocorticoid levels and respond normally to dexamethasone challenge. Here we report on the interaction between symptoms of chronic stress and anxiety in female rats by making use of the social instability model of anxiety. Subjects were exposed to alternating 24 h periods of isolation and moderate crowding for 14 days. Symptoms of chronic stress and anxiety-like behaviour in the social interaction test were evaluated on the 15th day, i.e. 1 day after the last crowding phase. Social instability resulted in decreased weight gain, and chronically elevated plasma glucocorticoid levels only in rats that showed high aggressiveness during the crowding phases. In contrast, anxiety-like behaviour was increased irrespective to crowding-related aggressiveness. Thus, the development of chronic stress symptoms and anxiety-like behaviour dissociated: the former was bound to crowding-induced aggressiveness (i.e. to a higher stress load), whereas the latter occurred also when such aggressiveness was low, and symptoms of chronic stress did not develop. This finding is consistent with human data, and suggests that stressful events lead to anxiety in both cases: when stressors do or do not lead to chronic stress responses. Studying the distinctive features of anxieties associated or not with chronic endocrine stress responses would enhance our understanding of this disorder.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012565706

Download citation: RISBibTeXText

PMID: 15811385

DOI: 10.1016/j.physbeh.2005.01.005


Related references

The behavioral and molecular evaluation of effects of social instability stress as a model of stress-related disorders in adult female rats. Stress 20(6): 549-561, 2017

Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats. Developmental Psychobiology 60(6): 651-663, 2018

Social instability in female rats: effects on anxiety and buspirone efficacy. Psychopharmacology 174(2): 197-202, 2004

Social instability stress in adolescence increases anxiety and reduces social interactions in adulthood in male Long-Evans rats. Developmental Psychobiology 55(8): 849-859, 2013

Chronic social instability stress in female rats: a potential animal model for female depression. Neuroscience 159(3): 982-992, 2009

Defeat is a major stressor in males while social instability is stressful mainly in females: Towards the development of a social stress model in female rats. Brain Research Bulletin 50(1): 33-39, 1999

Gender matters: the relationship between social anxiety and alcohol-related consequences. Plos one 9(12): E115361, 2014

Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats. Behavioural Brain Research 187(2): 228-238, 2008

Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress. Behavioural Brain Research 335: 8, 2017

Hippocampal cell proliferation and spatial memory performance after social instability stress in adolescence in female rats. Behavioural Brain Research 208(1): 23-29, 2010

Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress. Molecular Neurobiology 55(2): 1097-1111, 2018

Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Research 1443: 1-17, 2012

Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination. Journal of Neural Transmission 122(3): 349-355, 2015

Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: a protective role of antidepressants. Neuroscience Research 88: 74-83, 2014

Social anxiety and drinking refusal self-efficacy moderate the relationship between drinking game participation and alcohol-related consequences. American Journal of Drug and Alcohol Abuse 40(5): 388-394, 2014