+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a



Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a



Journal of Neuroimmunology 177(1-2): 201-208



The authors reported the neurological disease spectrum associated with autoantibodies against minor gangliosides GM1b and GalNAc-GD1a. IgG and IgM antibody reactivity against gangliosides GM1, GM2, GM1b, GD1a, GalNAc-GD1a and GQ1b was investigated in sera from 7000 consecutive patients who had various neurological conditions. The clinical diagnoses for 456 anti-GM1b-positive patients were Guillain-Barré syndrome (GBS, 71%), atypical GBS with preserved deep tendon reflexes (12%), Fisher syndrome (10%), Bickerstaff's brainstem encephalitis (2%), ataxic GBS (2%) and acute ophthalmoparesis (1%). For 193 anti-GalNAc-GD1a-positive patients, the diagnoses were GBS (70%), atypical GBS (16%), Fisher syndrome (10%) and Bickerstaff's brainstem encephalitis (3%). Of the patients with GBS or atypical GBS, 28% of 381 anti-GM1b-positive and 31% of 166 anti-GalNAc-GD1a-positive patients had neither anti-GM1 nor anti-GD1a antibodies. Of those patients with Fisher syndrome, Bickerstaff's brainstem encephalitis, ataxic GBS or acute ophthalmoparesis, 33% of 67 anti-GM1b-positive, and 52% of 25 anti-GalNAc-GD1a-positive patients had no anti-GQ1b antibodies. Autoantibodies against GM1b and GalNAc-GD1a are associated with GBS, Fisher syndrome and related conditions. These antibodies should provide useful serological markers for identifying patients who have atypical GBS with preserved deep tendon reflexes, ataxic GBS, Bickerstaff's brainstem encephalitis or acute ophthalmoparesis, especially for those who have no antibodies to GM1, GD1a or GQ1b. A method to prepare GM1b was developed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012575998

Download citation: RISBibTeXText

PMID: 16844234

DOI: 10.1016/j.jneuroim.2006.04.005


Related references

Bickerstaff's brainstem encephalitis associated with IgM antibodies to GM1b and GalNAc-GD1a. Journal of the Neurological Sciences 217(2): 225-228, 2004

Isolation and characterization of extremely minor gangliosides, GM1b and GD1a, in adult bovine brains as developmentally regulated antigens. The Journal of Biological Chemistry 265: 44-51, 1990

Antibody to GalNAc-GD1a and GalNAc-GM1b in Guillain-Barré syndrome subsequent to Campylobacter jejuni enteritis. Journal of Neuroimmunology 71(1-2): 155-161, 1996

Ataxic Guillain-Barré syndrome associated with anti-GM1b and anti-GalNAc-GD1a antibodies. Journal of Neurology 251(1): 24-29, 2004

Complex of GM1- and GD1a-like lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. Plos one 10(4): E0124004, 2015

A case of chronic inflammatory demyelinating neuropathy associated with antibodies to gangliosides GM1 and GalNAc-GD1a. Rinsho Shinkeigaku 37(3): 228-232, 1997

Structure of the monosialyl oligosaccharides derived from sa-livary gland mucin glycoproteins of the Chinese swiftlet genus Collocalia Characterization of novel types of extended core structure, Gal1-3 1-6 GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc GalNAc. Journal of Biological Chemistry 26214: 6650-6657, 1987

Chemoenzymatic synthesis of biotin-appended analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a for solid-phase applications and improved ELISA tests. Organic and Biomolecular Chemistry 9(16): 5809-5815, 2011

Identification of gangliosides recognized by IgG anti-GalNAc-GD1a antibodies in bovine spinal motor neurons and motor nerves. Brain Research 1227: 216-220, 2008

Serum IgM binding to gangliosides GalNAc-GD1a and GM2 Association with a chronic demyelinating sensory motor polyneuropathy. Neurology 54(7 Supp 3): A369, 2000

Amyotrophic lateral sclerosis associated with IgG anti-GalNAc-GD1a antibodies. Clinical Neurology and Neurosurgery 110(7): 722-724, 2008

Isolation and characterization of extremely minor gangliosides, GM1b and GD1 alpha, in adult bovine brains as developmentally regulated antigens. Journal of Biological Chemistry 265(14): 8144-8151, 1990

IgG anti-Galnac-GD1a antibodies bind to neuromuscular junctions of rat hemidiaphragm. Muscle and Nerve 46(5): 705-710, 2012

Severe sensory ataxia and demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1A antibodies. Muscle and Nerve 25(6): 828-836, 2002

Severe sensory ataxia demyelinating polyneuropathy with IgM anti-GM2 and GalNAc-GD1A antibodies. Muscle & Nerve 25(6): 828-836, 2002