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Stoichiometric tapasin interactions in the catalysis of major histocompatibility complex class I molecule assembly



Stoichiometric tapasin interactions in the catalysis of major histocompatibility complex class I molecule assembly



Immunology 114(3): 346-353



The assembly of major histocompatibility complex (MHC) class I molecules with their peptide ligands in the endoplasmic reticulum (ER) requires the assistance of many proteins that form a multimolecular assemblage termed the 'peptide-loading complex'. Tapasin is the central stabilizer of this complex, which also includes the transporter associated with antigen processing (TAP), MHC class I molecules, the ER chaperone, calreticulin, and the thiol-oxidoreductase ERp57.

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Accession: 012584824

Download citation: RISBibTeXText

PMID: 15720436

DOI: 10.1111/j.1365-2567.2005.02103.x


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