EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Structure-function relationship between analogues of the antibacterial peptide indolicidin. I. Synthesis and biological activity of analogues with increased amphipathicity and elevated net positive charge of the molecule


Structure-function relationship between analogues of the antibacterial peptide indolicidin. I. Synthesis and biological activity of analogues with increased amphipathicity and elevated net positive charge of the molecule



Bioorganicheskaia Khimiia 30(5): 458-465



ISSN/ISBN: 0132-3423

PMID: 15562965

DOI: 10.1023/b:rubi.0000043782.21640.c2

The antibacterial peptide indolicidin and a number of its analogues were obtained by solid phase synthesis. An optimized method of the synthesis using the Boc strategy was suggested.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012592211

Download citation: RISBibTeXText

Related references

Design and synthesis of indolicidin analogues with enhanced positive net charge and amphipathicity. Journal of Peptide Science 8(Suppl): S164, 2002

Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity. Bioorganic and Medicinal Chemistry Letters 14(11): 2857-2862, 2004

Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide. Journal of Peptide Science: An Official Publication of the European Peptide Society 16(4): 171-177, 2010

New indolicidin analogues with potent antibacterial activity. Journal of Peptide Research: Official Journal of the American Peptide Society 64(5): 171-185, 2004

Synthesis of caprazamycin analogues and their structure--activity relationship for antibacterial activity. Journal of Organic Chemistry 73(2): 569-577, 2008

Synthesis and biological characterization of indolicidin analogues. Journal of Biochemistry and Molecular Biology 30(3): 229-233, 1997

Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or terminally modified peptide chains. Experientia 32(2): 246-248, 1976

Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1). Journal of Medicinal Chemistry 57(3): 1127-1131, 2014

Chromone-fused cytosine analogues: synthesis, biological activity, and structure-activity relationship. Nucleosides Nucleotides and Nucleic Acids 33(2): 80-91, 2014

Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life Sciences 60(15): 1263-1269, 1997

Diaza-8,13 œstrones et analogues. I: Etude pharmacologique et modification de la molécule hétérostéroïdique en vue de l'établissement de relations structure-activité analgésique - 8, 13-Diazaoestrones and their analogues. I: Pharmacological study and modification of the heterosteroidal molecule for determination of analgesic structure activity relation. European Journal of Medicinal Chemistry 18(4): 319-329, 1983

Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structure-activity relationship studies. European Journal of Medicinal Chemistry 170: 99-111, 2019

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment. Acs Omega 5(12): 6967-6982, 2020

Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship. Bioorganic and Medicinal Chemistry Letters 12(17): 2303-2307, 2002

Synthesis, biological activities, and quantitative structure-activity relationship (QSAR) study of novel camptothecin analogues. Molecules 20(5): 8634-8653, 2015