+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Successful desensitization to oxaliplatin



Successful desensitization to oxaliplatin



Annals of PharmacoTherapy 39(5): 966-969



To report the successful desensitization of a patient to oxaliplatin utilizing an 8-hour desensitization regimen in a controlled environment. A 53-year-old white woman with metastatic colon cancer was receiving oxaliplatin, bevacizumab, and capecitabine every 2 weeks, with a partial response to therapy. On her fifth cycle of this regimen, she experienced diaphoresis, hypotension, nausea, abdominal cramping, and coryza. According to the Naranjo probability scale, oxaliplatin, and not bevacizumab, was the probable cause of the hypersensitivity reaction. The woman continued therapy with capecitabine and bevacizumab, resulting in stable disease. Due to her initial response to the oxaliplatin-based regimen, it was decided to attempt desensitization to oxaliplatin in a controlled, inpatient environment. An 8-hour desensitization schedule was employed, and the patient successfully completed an additional 3 cycles with full-dose oxaliplatin. Hypersensitivity reactions to platinum-containing compounds are well described and potentially life threatening. With expanded use of oxaliplatin in various malignancies, an increased number of hypersensitivity reactions will likely be reported. Patients with previous hypersensitivity reactions to carboplatin are at risk for similar reactions to oxaliplatin. We achieved successful desensitization for oxaliplatin using increased concentrations of the drug over an 8-hour period concomitant with oral and intravenous corticosteroids and histamine blockers. Hypersensitivity reactions to platinum compounds may result in discontinuation of active therapies in patients with metastatic disease. Desensitization to oxaliplatin is possible utilizing this approach.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012599187

Download citation: RISBibTeXText

PMID: 15784807

DOI: 10.1345/aph.1e532


Related references

Successful desensitization to oxaliplatin in a patient with oxaliplatin hypersensitivity. Journal of Allergy & Clinical Immunology 111(2 Abstract Suppl.): S289, 2003

Oxaliplatin hypersensitivity: case report and successful repeat desensitization. American Journal of Therapeutics 14(1): 116-118, 2007

Successful desensitization to oxaliplatin with incorporation of calcium gluconate and magnesium sulfate. Anti-Cancer Drugs 18(6): 721-724, 2007

Desensitization with oxaliplatin in patients intolerant of carboplatin desensitization. International Journal of Gynecological Cancer 24(9): 1603-1606, 2014

Successful rapid rituximab desensitization in an adolescent patient with nephrotic syndrome: Increase in number of Treg cells after desensitization. Journal of Allergy and Clinical Immunology 132(2): 478-480, 2013

Effectiveness of oxaliplatin desensitization protocols. Clinical and Translational Oncology 15(3): 219-225, 2013

Hypersensitivity reactions to oxaliplatin and the application of a desensitization protocol. Oncologist 9(5): 546-549, 2004

Hypersensitiveness to oxaliplatin Cutaneous tests and desensitization protocol. Atencion Farmaceutica 6(1): 28-30, 32-34, 2004

Readministration of oxaliplatin on a desensitization protocol in a patient with anaphylactic reaction. Journal of Allergy & Clinical Immunology 111(2 Abstract Suppl.): S173, 2003

Oxaliplatin hypersensitivity: evaluation, implications of skin testing, and desensitization. Journal of Allergy and Clinical Immunology. in Practice 2(1): 40-45, 2014

Oxaliplatin (Ox) desensitization in colorectal cancer (CRC) patients: A single institution experience. Journal of Clinical Oncology 26(15_Suppl): 15047-15047, 2016

A New Practical Desensitization Protocol for Oxaliplatin-Induced Immediate Hypersensitivity Reactions: A Necessary and Useful Approach. Journal of Investigational Allergology and Clinical Immunology 26(3): 168-176, 2016

Readministration of oxaliplatin using a rapid desensitization method after severe anaphylactic reaction. Gastroenterologie Clinique et Biologique 25(2): 206-207, 2001

Hypersensitivity reactions to oxaliplatin: a retrospective study and the development of a desensitization protocol. Clinical Colorectal Cancer 8(2): 106-109, 2009