+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Swertia chirayita mediated modulation of interleukin-1beta, interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha in arthritic mice

Swertia chirayita mediated modulation of interleukin-1beta, interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha in arthritic mice

Immunopharmacology and Immunotoxicology 25(4): 573-583

The effect of aqueous extract of Swertia chirayita stem on the pro- and anti-inflammatory cytokines balance in primary joint synovium of adjuvant-induced arthritic mice has been studied. The level of pro-inflammatory cytokines was found elevated in the joint synovium of arthritic mice in comparison to normal joints. Administration of S. chirayita extract in varying doses through the oral route did not modulate the proinflammatory cytokines on day 2. In contrast, by day 12, a dose dependent (0, 11.86 and 23.72 mg/kg body weight) reduction of tumor necrosis factor-alpha (INF-alpha) interleukin-1beta, (IL-beta) and interferon-gamma, (IFN-gamma) and elevation of Interleukin-10 (IL-10) was observed in the joint homogenates of arthritic mice. Interleukin-6 (IL-6) was not down regulated in joint homogenate of arthritic mice at the dose 11.86 mg/kg but at higher doses (23.72 and 35.58 mg/kg) significant reduction was observed. The aqueous extract was found to possess two polar compounds, amerogentin and mangiferin but was devoid of swerchirin, chiratol, methyl swetianin, and swertanone. Mangiferin has been reported to possess potent anti-inflammatory property and we presume its presence in the aqueous extract of S. chirayita is responsible for reducing TNF-alpha, IL-1beta, IL-6, and IFN-gamma and/or elevating IL-10 in the joint homogenates of arthritic mice on day 12. This study will help in our understanding of the mechanism of anti-inflammatory action of S. chirayita in the light of proinflammatory and anti-inflammatory cytokine balance.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012606870

Download citation: RISBibTeXText

PMID: 14686799

DOI: 10.1081/iph-120026442

Related references

Modulation of interleukin-1beta, interleukin-4, interleukin-6 interleukin-10, tumor necrosis factor-alpha and interferon-gamma by aqueous extracts of Swertia chirayita. Indian Journal of Pharmacology 34(2): 141, 2002

Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4. Shock 27(3): 226-231, 2007

Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-alpha and interleukin-1, but not by interferon-gamma nor interleukin-6. Aids 14(10): 1299-1307, 2000

Interleukin 1 interleukin 2 interleukin 4 interleukin 6 tumor necrosis factor alpha and interferon gamma levels in sera from patients with scleroderma. Arthritis & Rheumatism 35(1): 67-72, 1992

Complement factor I is upregulated in rat hepatocytes by interleukin-6 but not by interferon-gamma, interleukin-1beta, or tumor necrosis factor-alpha. Biological Chemistry 382(7): 1089-1094, 2001

Complement factor I is upregulated in rat hepatocytes and HUVEC by interleukin-6 but not by interferon-gamma, interleukin-1beta or tumor necrosis factor-alpha. Molecular Immunology 38(2-3): 84-85, 2001

Effect of tripterygium glycosides on serum interleukin-1beta, interleukin-2, tumor necrosis factor alpha, and interferon-gamma levels in patients with Behcet's disease. Zhongguo Zhong Xi Yi Jie he Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi 30(6): 598-600, 2010

Cytokine responses to intraventricular injection of interleukin 2 into patients with leptomeningeal carcinomatosis rapid induction of tumor necrosis factor alpha interleukin 1 beta interleukin 6 gamma interferon and soluble interleukin 2 receptor m r 55000 protein. Cancer Research 52(5): 1123-1128, 1992

Penetrability of interleukin-1beta and its effect on the concentration of tumor necrosis factor-alpha and interleukin-6 in the aqueous humor of rabbits treated with interleukin-1beta. Chinese Medical Journal 122(18): 2165-2168, 2009

Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Arthritis and Rheumatism 52(1): 84-93, 2005

Gene expression and production of tumor necrosis factor alpha, interleukin 1, interleukin 6, and gamma interferon in C3H/HeN and C57BL/6N mice in acute Mycoplasma pulmonis disease. Infection and Immunity 63(10): 4084-4090, 1995

Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 99(3): 276-284, 2005

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infection and Immunity 62(7): 2818-2824, 1994

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. Journal of Biological Chemistry 279(47): 49523-49532, 2004

Interleukin 1beta, interleukin-6, interleukin-8 and tumor necrosis factor alpha levels in newborns with sepsis. Pediatric Research 53(4 Part 2): 312A, 2003