Synthesis of a Tyr3-octreotate conjugated closo-carborane (HC2B10H10) : A potential compound for boron neutron capture therapy
Schirrmacher, E.; Schirrmacher, R.; Beck, C.; Mier, W.; Trautman, N.; Roesch, F.
Tetrahedron Letters 44(51): 9143-9145
ISSN/ISBN: 0040-4039 DOI: 10.1016/j.tetlet.2003.10.048
A novel Tyr3-octreotate conjugated closo-carborane as a potential compound for boron neutron capture therapy was obtained via Fmoc solid phase peptide synthesis. The boron cluster (C2B10H11) was introduced through the reaction of 6,9-bis(acetonitrile)decaborane and 5-hexynoic acid yielding a new closo-carborane conjugated carboxylic acid which was coupled subsequently with solid phase conjugated Tyr3-octreotate.