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Chapter 12,613

Synthesis of a Tyr3-octreotate conjugated closo-carborane (HC2B10H10) : A potential compound for boron neutron capture therapy

Schirrmacher, E.; Schirrmacher, R.; Beck, C.; Mier, W.; Trautman, N.; Roesch, F.

Tetrahedron Letters 44(51): 9143-9145

2003

ISSN/ISBN: 0040-4039
DOI: 10.1016/j.tetlet.2003.10.048
Accession: 012612253
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A novel Tyr3-octreotate conjugated closo-carborane as a potential compound for boron neutron capture therapy was obtained via Fmoc solid phase peptide synthesis. The boron cluster (C2B10H11) was introduced through the reaction of 6,9-bis(acetonitrile)decaborane and 5-hexynoic acid yielding a new closo-carborane conjugated carboxylic acid which was coupled subsequently with solid phase conjugated Tyr3-octreotate.

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