+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Synthetic peptide arrays and peptide combinatorial libraries for the exploration of protein-ligand interactions and the design of protein inhibitors



Synthetic peptide arrays and peptide combinatorial libraries for the exploration of protein-ligand interactions and the design of protein inhibitors



Combinatorial Chemistry & High Throughput Screening 8(2): 135-143



Synthetic peptides have a long tradition as molecular tools in biomedical research and drug discovery. The introduction of high-throughput synthesis and screening technologies for synthetic peptides, such as arrays and combinatorial libraries, enabled the large-scale and detailed exploration of protein-ligand interactions, as well as the discovery of novel biologically active peptides.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 012614413

Download citation: RISBibTeXText

PMID: 15777177


Related references

Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors. Current Pharmaceutical Design 16(28): 3071-3088, 2010

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Current Pharmaceutical Design 16(28): 3071-3088, 2011

The Bead blot: a method for identifying ligand-protein and protein-protein interactions using combinatorial libraries of peptide ligands. Analytical Biochemistry 361(1): 65-76, 2006

Multiplexed sorting of libraries on libraries: a novel method for empirical protein design by affinity-driven phage enrichment on synthetic peptide arrays. Molecular Diversity 8(3): 231-245, 2004

Mapping protein-protein interactions with phage-displayed combinatorial peptide libraries. Current Protocols in Cell Biology Chapter 17: Unit 17.4, 2008

Reverse interactomics: decoding protein-protein interactions with combinatorial peptide libraries. Molecular Biosystems 3(8): 536-541, 2007

Mapping protein-protein interactions with phage-displayed combinatorial peptide libraries and alanine scanning. Methods in Molecular Biology 1248: 173-188, 2015

G-protein-directed ligand discovery with peptide combinatorial libraries. Trends in Biochemical Sciences 30(6): 318-324, 2005

In-depth exploration of cow's whey proteome via combinatorial peptide ligand libraries. Journal of Proteome Research 8(8): 3925-3936, 2009

Exploration of the sea urchin coelomic fluid via combinatorial peptide ligand libraries. Biological Bulletin 222(2): 93-104, 2012

Protein biomarkers for early detection of diseases: The decisive contribution of combinatorial peptide ligand libraries. Journal of Proteomics 188: 1-14, 2017

Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences. Molecular Pharmacology 71(1): 323-332, 2006

In depth exploration of the hemolymph of Limulus polyphemus via combinatorial peptide ligand libraries. Journal of Proteome Research 9(6): 3260-3269, 2010

Combinatorial peptide ligand libraries for the analysis of low-expression proteins: Validation for normal urine and definition of a first protein MAP. Proteomics 12(4-5): 509-515, 2012

Computational design of combinatorial peptide library for modulating protein-protein interactions. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2005: 28-39, 2005