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T cell expansion is regulated by activated Gr-1+ splenocytes



T cell expansion is regulated by activated Gr-1+ splenocytes



Cellular Immunology 235(1): 39-45



CD4+ T cell proliferation depends on the balance between NO and extra-cellular superoxide (O2-). By reducing NO bio-availability, O2- promotes splenic T cell proliferation and immune response intensity. Here, we show that spleen cells from naïve mice produced neither NO nor O2- during T cell activation, but Gr-1+ splenocytes from primed mice regulated Ag-specific T cell expansion via production of both molecules. Purified splenic Gr-1+ cells included mostly granulocytes at various stages of maturation, as well as monocytes. Activation or recruitment of regulatory Gr-1+ cells was dependent on immunization with CFA. Importantly, these regulatory cells were not detected in draining lymph nodes. These data suggest that innate Gr-1+ splenic cells regulate adaptive immunity.

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Accession: 012615886

Download citation: RISBibTeXText

PMID: 16083869

DOI: 10.1016/j.cellimm.2005.06.008


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