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Telomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT)

Ito, Y.; Yoshida, H.; Tomoda, C.; Uruno, T.; Takamura, Y.; Miya, A.; Kobayashi, K.; Matsuzuka, F.; Kuma, K.; Miyauchi, A.

Anticancer Research 25(1b): 509-514

2005

ISSN/ISBN: 0250-7005
PMID: 15816620
Accession: 012621735
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Background: The recent availability of a monoclonal antibody against human telomerase reverse transcriptase (hTERT) has enabled us to investigate the telomerase activity of tissue specimens more easily than by classical TRAP assay. In this study, we studied teromerase activity in thyroid tumors using this antibody. Materials and Methods: We immunohistochemically investigated hTERT expression in 166 thyroid neoplasms. Results: Normal follicular cells did not express hTERT.

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