+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

The Helix aspersa (brown garden snail) allergen repertoire

The Helix aspersa (brown garden snail) allergen repertoire

International Archives of Allergy and Immunology 136(1): 7-15

ISSN/ISBN: 1018-2438

PMID: 15591808

DOI: 10.1159/000082579

Ingestion of snails can induce strong asthmatic or anaphylactic responses, mainly in house-dust-mite-sensitized patients. The aim of this study was to identify the Helix aspersa (Hel a), Theba pisana (The p) and Otala lactea (Ota l) allergens and the extent of their cross-reactivity with the Dermatophagoides pteronyssinus (Der p) mite. In 60 atopic patients, skin prick tests (SPT) to snail and D. pteronyssinus, total and specific IgE, specific IgE immunoblots, RAST and immunoblot inhibition assays were performed. Mean total IgE was >1,000 kU/l. Mean specific IgE (class 6 for Der p and class 2 for Hel a) SPT were positive in 44 patients for snail and in 56 for mite. Isoelectric focusing (IEF) and SDS-PAGE followed by immunoblotting of H. aspersa extract enabled the identification of 27 and 20 allergens, respectively. Myosin heavy chains from snails (molecular weight >208 kDa) disclosed two major allergens. Hel a and Der p RAST were strongly inhibited by their homologous extracts, with Hel a RAST being inhibited by the Der p extract to a much greater extent (72.6%) than the inverse (5.6%). A complete inhibition of the immunoblots by their homologous extract was obtained. However, Hel a extract did not inhibit Der p IEF separated recognition. On the other hand, mite extract extensively inhibited snail immunoblots from both IEF and SDS-PAGE separations. Immune detection on chicken, pig, rabbit, cow and horse myosins did not reveal any IgE cross recognition with snail. In most cases of snail allergy, mite appeared to be the sensitizing agent. Nevertheless, snails may also be able to induce sensitization by themselves. This hypothesis is supported by the finding of specific IgE to Hel a in 2 patients who did not show specific IgE to Der p, and one of them was suffering from asthma after snail ingestion.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012629772

Download citation: RISBibTeXText

Related references

Variability of the brown garden snail helix aspersa. Bulletin du Museum National d'Histoire Naturelle Zoologie 311: 425-442, 1977

Importance de la lumière sur la croissance pondérale de l'escargot petit-gris (Helix aspersa Müller) (mollusque gasteropode pulmoné) - Importance of light on the growth weight on the brown garden snail (Helix aspersa Müller) (Mollusca, gastropoda, Pulmonata). Societe Francaise de Malacologie. Congres 6 (1985) 15: 115-124, 1986

Antimicrobial properties of mucus from the brown garden snail Helix aspersa. British Journal of Biomedical Science 72(4): 174-81; quiz 208, 2015

Helix aspersa Muller, brown garden snail (Stylommatophora: Helicidae). Technical communication Commonwealth Institute of Biological Control: 0) 93-95, 1989

Biology of brown garden snail helix aspersa mueller stylommatophora helicidae. Research Bulletin of the Plant Protection Service Japan 24: 7-14, 1988

Biology of brown garden snail, Helix aspersa Muller Stylommatophora Helicidae. Research Bulletin of the Plant Protection Service Japan 24: 7-13, 1988

Cloning, isolation, and IgE-binding properties of Helix aspersa (brown garden snail) tropomyosin. International Archives of Allergy and Immunology 128(2): 90-96, 2002

Molluscicidal activity of certain weed extracts and fertilizers against the brown garden snail, Helix aspersa. Annals of Agricultural Science Cairo 42(2): 687-695, 1997

Efficacy and phytotoxicity of selected pesticides for the suppression of the brown garden snail, Helix aspersa. Journal of environmental horticulture 2(4): 109-111, 1984

Laboratory study of calcium requirements of the brown garden snail, Helix aspersa Muller. Proceedings of the Malacological Society of London 406: 491-503, 1973

The garden snail Helix aspersa and gastronomy El caracol de jardin Helix aspersa y la Gastronomia. Sociedad Internacional de Malacologia Medica y Aplicada Boletin. noviembre; 14: 7-9, 2003

Field trials with toxic bait for the control of the brown garden snail (Helix aspersa, Müller). S. Afr. J. Enol. Vitic 8(2): 80-81, 1987

Effects of dietary exposure to forest pesticides on the brown garden snail Helix aspersa Mueller. Archives of Environmental Contamination and Toxicology 26(1): 23-28, 1994

Infections of Larval Stages of Dicrocoelium dendriticum and Brachylaima sp. in Brown Garden Snail, Helix aspersa, in Turkey. Korean Journal of Parasitology 53(5): 647-651, 2015

Relation entre la teneur en eau, l'excrétion azotée et la thermohygrométrie ambiante chez le jeune escargot petit-gris (Helix aspersa Müller) (mollusque gastéropode pulmoné) - Relation between the water content, nitorgen excretion and the ambient hygrometry in the young brown garden snail (Helix aspersa Müller) (gastropoda, Pulmonata). Societe Francaise de Malacologie. Congres 6 (1985) 15: 217-230, 1986