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The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors

The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors

Journal of Immunology 175(9): 6107-6116

The mechanisms underlying the extrathymic generation of CD25(+)CD4 regulatory T cells (Tregs) are largely unknown. In this study the IL-4R alpha-chain-binding cytokines, IL-4 and IL-13, were identified as inducers of CD25(+) Tregs from peripheral CD25(-)CD4 naive T cells.

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Accession: 012629902

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PMID: 16237107

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