+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The Notch and Sonic hedgehog signalling pathways in immunity

The Notch and Sonic hedgehog signalling pathways in immunity

Molecular Immunology 41(6-7): 715-725

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012631197

Download citation: RISBibTeXText

PMID: 15220006

DOI: 10.1016/j.molimm.2004.04.017

Related references

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 27(10): 1489-1500, 2007

Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1. Canadian Journal of Gastroenterology & Hepatology 29(4): 209-217, 2016

Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. Journal of Cellular Biochemistry 102(4): 829-839, 2007

Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histology and Histopathology 24(3): 385-398, 2009

Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Molecular Medicine 17(1-2): 103-112, 2011

Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development 131(6): 1289-1298, 2004

Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Developmental Biology 298(1): 167-175, 2006

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. International Journal of Biochemistry & Cell Biology 42(9): 1462-1471, 2010

A Notch above Sonic Hedgehog. Developmental Cell 33(4): 371-372, 2015

The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental Dermatology 23(12): 896-901, 2015

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Developmental Cell 33(4): 373-387, 2015

Notch signaling facilitates sonic hedgehog expression in Xenopus laevis embryos. Journal of Neurochemistry 78(Supplement 1): 56, September, 2001

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Research 69(8): 3249-3255, 2009

Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis. Basic Research in Cardiology 105(1): 61-71, 2010

Discovery of sonic hedgehog expression in postnatal growth plate chondrocytes: differential regulation of sonic and Indian hedgehog by retinoic acid. Journal of Cellular Biochemistry 87(2): 173-187, 2002