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The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end


The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end



Biochemistry 45(35): 10572-10583



ISSN/ISBN: 0006-2960

PMID: 16939209

DOI: 10.1021/bi060491l

The crystal structure of the ternary complex of (alpha beta)(2) heterotetrameric phenylalanyl-tRNA synthetase (PheRS) from Thermus thermophilus with cognate tRNA(Phe) and a nonhydrolyzable phenylalanyl-adenylate analogue (PheOH-AMP) has been determined at 3.1 angstrom resolution. It reveals conformational changes in tRNAPhe induced by the PheOH-AMP binding.

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Accession: 012641478

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