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The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm

The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm

Developmental Biology 285(2): 477-489

ISSN/ISBN: 0012-1606

PMID: 16102745

DOI: 10.1016/j.ydbio.2005.07.019

In the current analysis, we have investigated both the cytoskeletal and signaling roles of P-catenin during the early phases of lens development using conditional loss- and gain-of-function strategies. Conditional loss of beta-catenin in the presumptive lens does not perturb the normal sequential appearance of lens fate markers but results in a dramatic failure of the coordinated epithelial cell behavior that constitutes lens morphogenesis.

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Accession: 012643811

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