+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing

The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing

Human Reproduction 19(10): 2289-2297

This is the first study to assess the outcome of sperm washing and intrauterine insemination (IUI) cycles in human immunodeficiency virus-positive (HIV(+)) men to determine any predictors of success, as well as evaluating the effect of HIV on sperm parameters. Semen characteristics were evaluated in 106 HIV(+) men and a control group of 234 HIV(-) men, and the effect of markers of HIV disease assessed. Age, stimulation regime, sperm parameters, markers of HIV disease and the use of anti-retrovirals were assessed as predictors of the outcome of sperm washing/IUI cycles in the HIV(+) men. Ejaculate volume, sperm concentration, total count, progressive motility and normal morphology were all significantly higher in the control group compared to the HIV(+) men (P<0.05). A significant positive correlation was observed between CD4 count and sperm concentration, total count, motility, progressive motility type 'a'+'b' and post-preparation concentration and a significant negative correlation with normal sperm morphology of both raw and post-preparation samples. No correlation was observed between viral load (VL), years since diagnosis, use of anti-retrovirals or duration of use and any sperm parameter. The only factors that significantly improved IUI outcome were a VL <1000 copies/ml and the use of anti-retrovirals. These data demonstrate that sperm parameters are significantly impaired by the presence of HIV infection and in particular correlate with CD4 count. Undetectable VL and the use of anti-retrovirals improve the outcome of IUI/sperm washing in HIV(+) men.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 012646535

Download citation: RISBibTeXText

PMID: 15242991

DOI: 10.1093/humrep/deh426

Related references

The Effect of Human Immunodeficiency Virus on Sperm Parameters and the Outcome of Intrauterine Insemination Following Sperm Washing. Yearbook of Obstetrics Gynecology and Women's Health 2006: 193-194, 2006

Effect of insemination timing on pregnancy outcome in association with female age, sperm motility, sperm morphology and sperm concentration in intrauterine insemination. Journal of Obstetrics and Gynaecology Research 44(6): 1100-1106, 2018

Synchronous sperm retrieval and sperm washing in an intracytoplasmic sperm injection cycle in an azoospermic man who was positive for human immunodeficiency virus. Fertility and Sterility 81(3): 670-674, 2004

Effect of postprepared sperm parameters and insemination specimen volume on the outcome of intrauterine insemination. Changgeng Yi Xue Za Zhi 21(3): 265-270, 1998

Processing method of frozen donor sperm correlates with final sperm parameters and intrauterine insemination pregnancy outcome. Journal of Andrology 0(Suppl. ): P45, 1997

Effect of sperm morphology and motile sperm count on outcome of intrauterine insemination in oligozoospermia and/or asthenozoospermia. Fertility and Sterility 53(5): 892-897, 1990

The effect of intrauterine insemination and sperm washing on sex ratio. The American Fertility Society Scientific Papers to Be Presented at The 43rd Annual Meeting Of The American Fertility Society, Reno, Nevada, Usa, September 28-30, Xxii+134p The American Fertility Society: Birmingham, Alabama, Usa Paper : 97, 1987

The effects of the human immunodeficiency virus on semen parameters and intrauterine insemination outcome. Human Reproduction 20(7): 2033-4; Author Reply 2034-5, 2005

Does sperm morphology affect the outcome of intrauterine insemination in patients with normal sperm concentration and motility?. Andrologia 44(5): 299-304, 2012

The influence of sperm morphology and the number of motile sperm inseminated on the outcome of intrauterine insemination combined with mild ovarian stimulation. Fertility and Sterility 65(1): 127-132, 1996

The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI. Human Reproduction 19(6): 1401-1408, 2004

The influence of sperm morphology, total motile sperm count of semen and the number of motile sperm inseminated in sperm samples on the success of intrauterine insemination. International Journal of Fertility and Sterility 5(3): 168-173, 2011

Simplified sperm washing techniques and intrauterine insemination. Obstetrics and Gynecology 71(2): 277-279, 1988

Washing, selection and sperm precapacitation. Intrauterine insemination I. Ginecologia Y Obstetricia de Mexico 55: 226-231, 1987

Effect of sperm parameters on intrauterine insemination pregnancy rate. Journal of the College of Physicians and Surgeons--Pakistan 18(6): 342-346, 2008