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The orthopaedic approach to managing osteoarthritis of the knee



The orthopaedic approach to managing osteoarthritis of the knee



BMJ 329(7476): 1220-1224



Although p53-inactivating mutations have been described in the majority of human cancers, their role in prostate cancer is controversial as mutations are uncommon, particularly in early lesions. p53 is activated by hypoxia and other stressors and is primarily regulated by the Mdm2 protein. Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and other eicosanoids, is also induced by hypoxia.

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Accession: 012669454

Download citation: RISBibTeXText

PMID: 15550426

DOI: 10.1136/bmj.329.7476.1220


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