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The orthopaedic approach to managing osteoarthritis of the knee

The orthopaedic approach to managing osteoarthritis of the knee

BMJ 329(7476): 1220-1224

Although p53-inactivating mutations have been described in the majority of human cancers, their role in prostate cancer is controversial as mutations are uncommon, particularly in early lesions. p53 is activated by hypoxia and other stressors and is primarily regulated by the Mdm2 protein. Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and other eicosanoids, is also induced by hypoxia.

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Accession: 012669454

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PMID: 15550426

DOI: 10.1136/bmj.329.7476.1220

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