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Chapter 12,673

The presynaptic activity of bothropstoxin-I, a myotoxin from Bothrops jararacussu snake venom

Oshima-Franco, Y.; Leite, G.Bernardo.; Belo, Cáriston.André.Dal.; Hyslop, S.; Prado-Franceschi, Júlia.; Cintra, Aélia.Cristina.Oliveira.; Giglio, Jé.Roberto.; da Cruz-Höfling, M.Alice.; Rodrigues-Simioni, Léa.

Basic and Clinical Pharmacology and Toxicology 95(4): 175-182

2004

ISSN/ISBN: 1742-7835
PMID: 15504153
DOI: 10.1111/j.1742-7843.2004.pto_950405.x
Accession: 012672327
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Bothropstoxin-I from Bothrops jararacussu snake venom is a lysine-49 phospholipase A2 with myotoxic and neurotoxic activities. In this study, we used mouse phrenic nerve-diaphragm preparations in the absence and presence of manganese (Mn2+), a presynaptic blocker, to investigate a possible presynaptic action of bothropstoxin-I. At concentrations of 0.9 mM and 1.8 mM, Mn2+ produced 50% neuromuscular blockade in less than 4 min., which was spontaneously reversible at the lower concentration.

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