+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece: a Hellenic Cooperative Oncology Group Study



The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece: a Hellenic Cooperative Oncology Group Study



Acta Haematologica 112(4): 189-193



Our aim was to investigate the association between chronic hepatitis C virus (HCV) infection and B cell non-Hodgkin lymphoma (NHL) in the Greek population. We studied 120 patients (70 men and 50 women, mean age 59 years) diagnosed with NHL. One hundred and eight had B cell NHL (90%) and 12 had T cell NHL (10%). The presence of anti-HCV antibodies in patients and controls was investigated using the monoclonal enzymatic immunoassay (MEIA) method. The detection of HCV RNA and hepatitis G virus (HGV) RNA in patients with B cell NHL and anti-HCV-positive controls was performed using an RT-PCR technique. Anti-HCV antibodies were present in only 2 of the 108 patients with B cell NHL (1.9%), while the prevalence of HCV infection in the healthy population was 0.6%, and in patients with various solid tumors treated with chemotherapy, it was 0.99%. Ten of the 108 B cell NHL patients (9.26%) were diagnosed as HGV RNA positive, while the prevalence of HGV infection in 285 Greek blood donors was 0.7%. Our findings do not confirm a strong association between HCV infection and B cell NHL for Greek patients. The increased prevalence of HGV infection detected in patients with NHL could imply the potential participation of HGV in the pathogenesis of NHL.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012672476

Download citation: RISBibTeXText

PMID: 15564729

DOI: 10.1159/000081270


Related references

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers. British Journal of Haematology 109(1): 249-250, 2000

Diffuse large cell lymphomas: identification of prognostic factors and validation of the International Non-Hodgkin's Lymphoma Prognostic Index. A Hellenic Cooperative Oncology Group Study. Oncology 55(5): 405-415, 1998

High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: absence of correlation with hepatitis C virus infection. Haematologica 87(7): 714-8; Discussion 718, 2002

Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. The VA Cooperative Study Group (No. 119). Hepatology 14(4 Pt 1): 581-589, 1991

Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infection Among Patients With Newly Diagnosed Cancer From Academic and Community Oncology Practices. JAMA Oncology 5(4): 497-505, 2019

Multifocal extranodal non-hodgkin lymphoma: a clinicopathologic study of 37 cases in Greece, a Hellenic Cooperative Oncology Group study. Oncologist 10(9): 734-738, 2005

Prevalence of hepatitis C infection in patients with non-Hodgkin's lymphomas. Oncology Reports 9(3): 657-659, 2002

Primary gastrointestinal non-Hodgkin's lymphoma: a clinicopathologic study of 128 cases in Greece. A Hellenic Cooperative Oncology Group study (HeCOG). Leukemia and Lymphoma 47(10): 2140-2146, 2006

BCL-2 Expression correlates with lower proliferative activity in the intermediate- and high-grade non-Hodgkin's lymphomas: An Eastern Cooperative Oncology Group and the Southwest Oncology Group and Southwest Oncology Group Cooperative Laboratory Study. Blood 91(4): 1391-1398, 1998

Prevalence of hepatitis-G virus and hepatitis-C virus infection in patients with non-Hodgkin's lymphoma. Medical Oncology 17(2): 123-126, 2000

High prevalence of hepatitis C virus infection and favorable prognosis in primary hepatic non-Hodgkin lymphomas. Blood 94(10 Suppl. 1 Part 2): 245b, 1999

Prevalence of hepatitis C virus infection in B-cell non Hodgkin lymphoma patients in India. 2007

Epithelial ovarian cancer in Greece: a retrospective study of 1,791 patients by the Hellenic Cooperative Oncology Group (HeCOG). Anticancer Research 29(2): 745-751, 2009

High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin's lymphoma. Annals of Hematology 87(6): 475-480, 2008

High prevalence of hepatitis B virus infection in patients with B-cell non-Hodgkin's lymphoma in Korea. Journal of Medical Virology 80(6): 960-966, 2008