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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A beta generation in vivo


The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A beta generation in vivo



EMBO (European Molecular Biology Organization) Journal 25(2): 432-443



The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD). Here we show that seladin-1-deficient mouse brains had reduced levels of cholesterol and disorganized cholesterol-rich detergent-resistant membrane domains (DRMs).

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