+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A beta generation in vivo

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A beta generation in vivo

EMBO (European Molecular Biology Organization) Journal 25(2): 432-443

The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD). Here we show that seladin-1-deficient mouse brains had reduced levels of cholesterol and disorganized cholesterol-rich detergent-resistant membrane domains (DRMs).

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 012679523

Download citation: RISBibTeXText

Related references

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Ab generation in vivo. The EMBO Journal 25(2): 2-43, 2006

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. Embo Journal 25(2): 432-443, 2006

Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis. Postepy Higieny i Medycyny Doswiadczalnej 63: 318-330, 2009

The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10(8): 1699-1705, 1999

Role of Cholesterol in the in Vivo Biosynthesis of Adrenal Steroids by the Dog. Endocrinology 74: 543-547, 1964

Concerning the role of 4 beta methyl sterols in cholesterol biosynthesis. Journal of the American Chemical Society 97(12): 3522-3524, 1975

The Intermediary Role of Delta-5,7-Cholestadien-3-Beta-Ol in Cholesterol Biosynthesis. Journal of Biological Chemistry 239: 1381-1387, 1964

The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. Biochemical Journal 111(5): 757-761, 1969

The role of cholesterol in the processing beta-secretase Asp-2. Biochemical Society Transactions 30(3): A83, 2002

The role of cholesterol in beta processing of APP in Alzheimers disease. Journal of the Neurological Sciences (203-204): 328, 2002

The role of intracellular cholesterol on the processing of the beta-amyloid precursor protein. Journal of Nutrition Health and Aging 7(1): 31-36, 2003

The pathway for the removal of the 15 alpha methyl group of lanosterol the role of lanost 8 ene 3 beta 32 diol in cholesterol biosynthesis. Bioorganic Chemistry 6(4): 473-482, 1977

Studies of cholesterol biosynthesis. II. The role of desmosterol in the biosynthesis of cholesterol. Jour Biol Chem 235(11): 3127-3129, 1960

Cholesterol and Alzheimer's disease: statins, cholesterol depletion in APP processing and Abeta generation. Sub-Cellular Biochemistry 38: 365-380, 2005

Biosynthesis of R-(+)-octane-1,3-diol. Crucial role of beta-oxidation in the enantioselective generation of 1,3-diols in stored apples. Lipids 34(6): 617-625, 1999