The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines
Pimpinelli, F.; Lehmann, S.; Maridonneau-Parini, I.
European Journal of Neuroscience 21(8): 2063-2072
2005
ISSN/ISBN: 0953-816X PMID: 15869502 DOI: 10.1111/j.1460-9568.2005.04049.x
Accession: 012680783
Transmissible prion diseases are fatal neurodegenerative diseases associated with the conversion of the normal host prion protein (PrPc) into an abnormal isoform (PrPSc) that accumulates in brain. This pathology affects neurons of the central nervous system whereas no clear toxic effect has been reported for peripheral neurons.
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