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Cranial nerves of Labeo rohita (Ham.)
Cytogenetic analysis of ZZWW triploid silkworm (Bombyx mori)
Effectiveness of posterior crossbite correction during the mixed dentition
Classification of liver cirrhosis based on parenchymal echo patterns and its clinical usefulness for diagnosis of liver cirrhosis
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Furunculosis and pseudofurunculosis
Some Biological Applications of Organometallic Compounds
Stassanisation of Milk
Pulse rate, respiration, and body temperature of Philippine carabaos
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Enterobacter amnigenus. An unusual human pathogen
Vitamin B12 deficiency as a worldwide problem
Therapy for acne with saccharomyces boulardii
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The Difil Test kit for detection of canine heartworm microfilariae
Gafner Mini-skidder
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Mycotechnology: the role of fungi in biotechnology
On the nature and role of vivotoxins in plant disease
A study on compatibility of some insecticides with a fungicide on small cardamom (Elettaria cardamomum Maton.)
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season

The search for a tuberculosis vaccine: an elusive quest?


The search for a tuberculosis vaccine: an elusive quest?



Tuberculosis 86(1): 41-46



ISSN/ISBN: 1472-9792

PMID: 16253559

DOI: 10.1016/j.tube.2005.06.001

The precise mechanisms of protective immunity and pathogenesis of tuberculosis (TB) are poorly understood. Yet, many efforts are underway to develop new, more effective vaccines against Mycobacterium tuberculosis. This development appears to be predicated upon the assumption that natural acquired immunity to TB exists. In this paper we review the evidence for such immunity, explore the hypothesis that disease progression is due to some, often transient, immunological dysfunction, and discuss its relevance for vaccine development. Several mechanisms for such an immune dysfunction are proposed, including the recently suggested involvement of viral co-infections. Developing vaccines for such co-infections may be a new challenge for TB control.

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Accession: 012680810

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