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Cranial nerves of Labeo rohita (Ham.)
Cytogenetic analysis of ZZWW triploid silkworm (Bombyx mori)
Effectiveness of posterior crossbite correction during the mixed dentition
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The search for a tuberculosis vaccine: an elusive quest?

The search for a tuberculosis vaccine: an elusive quest?

Tuberculosis 86(1): 41-46

ISSN/ISBN: 1472-9792

PMID: 16253559

DOI: 10.1016/

The precise mechanisms of protective immunity and pathogenesis of tuberculosis (TB) are poorly understood. Yet, many efforts are underway to develop new, more effective vaccines against Mycobacterium tuberculosis. This development appears to be predicated upon the assumption that natural acquired immunity to TB exists. In this paper we review the evidence for such immunity, explore the hypothesis that disease progression is due to some, often transient, immunological dysfunction, and discuss its relevance for vaccine development. Several mechanisms for such an immune dysfunction are proposed, including the recently suggested involvement of viral co-infections. Developing vaccines for such co-infections may be a new challenge for TB control.

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Accession: 012680810

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