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The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles

EMBO (European Molecular Biology Organization) Journal 24(3): 452-463

Cyclin E, an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression in metazoans and is frequently overexpressed in cancer cells. It is essential for entry to the cell cycle from G0 quiescent phase, for the assembly of prereplication complexes and for endoreduplication in megakaryotes and giant trophoblast cells. We report the crystal structure of pCDK2 in complex with a truncated cyclin E1 ( residues 81 - 363) at 2.25 ANG resolution.

Accession: 012683155

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PMID: 15660127

DOI: 10.1038/sj.emboj.7600554

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