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The transient receptor potential superfamily of ion channels



The transient receptor potential superfamily of ion channels



Journal of the American Society of Nephrology 15(7): 1690-1699



ABSTRACT. The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM, TRPP, TRPN, and TRPML subfamilies. TRP channels are widespread and have diverse functions, ranging from thermal, tactile, taste, osmolar, and fluid flow sensing to transepithelial Ca2+ and Mg2+ transport. Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions.

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Accession: 012685139

Download citation: RISBibTeXText

PMID: 15213256

DOI: 10.1097/01.ASN.0000129115.69395.65


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