The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons
Strand, S.S.; Vanheyningen, T.K.; Leib, D.A.
Journal of Virology 78(15): 8400-8403
2004
ISSN/ISBN: 0022-538X
PMID: 15254212
DOI: 10.1128/jvi.78.15.8400-8403.2004
Accession: 012688096
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
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Related References
Zelus, B.D.; Stewart, R.S.; Ross, J. 1996: The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro Journal of Virology 70(4): 2411-2419You, H.; Yuan, H.; Fu, W.; Su, C.; Wang, W.; Cheng, T.; Zheng, C. 2017: Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein Antiviral Research 143: 69-73
Hill, T.M.; Sadler, J.R.; Betz, J.L. 1985: Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186 Journal of Virology 56(1): 312-316
Murphy, J.A.; Duerst, R.J.; Smith, T.J.; Morrison, L.A. 2003: Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo Journal of Virology 77(17): 9337-9345
Karr, B.; Read, G.S. 1991: Production of antisera to the virion host shutoff protein of herpes simplex virus type 1 Abstracts of the General Meeting of the American Society for Microbiology 91: 329
Everly, D.N.; Feng, P.; Mian, I.Saira.; Read, G.Sullivan. 2002: MRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: Genetic and biochemical evidence that Vhs is a nuclease Journal of Virology 76(17): 8560-8571
Poon, A.P.; Roizman, B. 1997: Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant gamma (1)34.5 genes of herpes simplex virus 1 Virology 229(1): 98-105
Poon, A.P.W.; Roizman, B. 1997: Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant c134.5 genes of herpes simplex virus 1 Virology 229: 105
Wise, E.L.; Samolej, J.; Elliott, G. 2022: Herpes Simplex Virus 1 Expressing GFP-Tagged Virion Host Shutoff (vhs) Protein Uncouples the Activities of RNA Degradation and Differential Nuclear Retention of the Virus Transcriptome Journal of Virology 96(14): E0192621
Duerst, R.J.; Morrison, L.A. 2004: Herpes simplex virus 2 virion host shutoff protein interferes with type i interferon production and responsiveness Virology 322(1): 158-167
Leib, D.A.; Strelow, L. 1997: The virion host shutoff function of herpes simplex virus type 1 and ocular infection A role for vhs in primary replication and corneal invasion IOVS Investigative Ophthalmology and Visual Science 38(4 Part 1-2): S725
Korom, M.; Wylie, K.M.; Morrison, L.A. 2008: Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice Journal of Virology 82(7): 3642-3653
Nichol, P.F.; Chang, J.Y.; Greenlund, L.S.; Olivo, P.; Johnson, E.M.Jr 1992: Cultured postmitotic neurons do not undergo virion-mediated host cell shutoff of protein synthesis after infection with herpes simplex virus-1 A unique response in neurons and a promising result for HSV-1 vector technology Society for Neuroscience Abstracts 18(1-2): 1330
Walker, J.; Leib, D.A. 1998: Protection from primary infection and establishment of latency by vaccination with a herpes simplex virus type 1 recombinant deficient in the virion host shutoff (vhs) function Vaccine 16(1): 1-5
Lu, P.; Jones, F.E.; Saffran, H.A.; Smiley, J.R. 2001: Herpes simplex virus virion host shutoff protein requires a mammalian factor for efficient in vitro endoribonuclease activity Journal of Virology 75(3): 1172-1185
Sarma, N.; Agarwal, D.; Shiflett, L.A.; Read, G.Sullivan. 2008: Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus Journal of Virology 82(13): 6600-6609
Knez, J.; Bilan, P.T.; Capone, J.P. 2003: A single amino acid substitution in herpes simplex virus type 1 VP16 inhibits binding to the virion host shutoff protein and is incompatible with virus growth Journal of Virology 77(5): 2892-2902
Taddeo, B.; Zhang, W.; Roizman, B. 2010: Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase Journal of Virology 84(19): 10182-10190
Krikorian, C.R.; Read, G.S. 1991: In vitro mRNA degradation system to study the virion host shutoff function of herpes simplex virus Journal of Virology 65(1): 112-122
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