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The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons

Strand, S.S.; Vanheyningen, T.K.; Leib, D.A.

Journal of Virology 78(15): 8400-8403

2004


ISSN/ISBN: 0022-538X
PMID: 15254212
DOI: 10.1128/jvi.78.15.8400-8403.2004
Accession: 012688096

The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.

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