+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction



Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction



Atherosclerosis 175(1): 91-94



Recent studies suggest that the chemokine eotaxin may participate in atherosclerosis. Threonine (T) for alanine (A) substitution at amino acid 23 in the eotaxin gene (CCL11) has been associated with risk of developing allergic-inflammatory disorders. However, no genetic-epidemiological data are available on the risk of cardiovascular disease associated with this polymorphism. Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we evaluated the A23T polymorphism among 523 individuals who subsequently developed myocardial infarction (MI) and among 2092 individuals who remained free of reported cardiovascular disease over a mean follow-up period of 13.2 years. The T23 allele was significantly associated with risk of myocardial infarction (odds ratio (OR) in an age and smoking adjusted recessive model of inheritance, 1.86; 95% confidence interval (CI), 1.15-3.01; P = 0.012). This risk effect remained statistically significant in analyses further controlling for body mass index, history of hypertension, the presence of diabetes, and randomized treatment assignment (OR, 1.95; 95% CI, 1.19-3.18; P = 0.008). In this cohort, a T for A substitution at amino acid 23 in the eotaxin gene is associated with increased risk for incident myocardial infarction. If confirmed in other cohorts, these data support the emerging hypothesis that eotaxin participates in atherosclerosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012693012

Download citation: RISBibTeXText

PMID: 15186951

DOI: 10.1016/j.atherosclerosis.2004.01.042


Related references

Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arteriosclerosis Thrombosis and Vascular Biology 23(5): 859-863, 2003

Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. American Journal of Gastroenterology 103(9): 2184-2193, 2008

An A23T missense polymorphism of the eotaxin gene and the risk of myocardial infarction. Circulation 108(17 Suppl.): IV-772, 2003

CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2. Journal of Leukocyte Biology 94(2): 213-222, 2013

Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. Cytokine 50(2): 181-185, 2010

Tryptophanyl-tRNA synthetase gene polymorphisms and risk of incident myocardial infarction. Atherosclerosis 181(1): 137-141, 2005

Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast. Biological & Pharmaceutical Bulletin 29(6): 1102-1109, 2006

Bovine eotaxin (CCL11)--an unusual member of the eotaxin group--attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary. Veterinary Immunology and Immunopathology 107(1-2): 67-77, 2005

Eotaxin/CCL11 levels correlate with myocardial fibrosis and mast cell density in native and transplanted rat hearts. Transplantation Proceedings 42(7): 2763-2766, 2010

Changes in short- and long-term cardiovascular risk of incident diabetes and incident myocardial infarction--a nationwide study. Diabetologia 53(8): 1612-1619, 2010

Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study. American Journal of Hypertension 26(10): 1210-1217, 2013

Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke. Stroke 37(7): 1686-1690, 2006

Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. Clinical Chemistry 52(11): 2021-2027, 2006

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. Atherosclerosis 197(2): 694-699, 2008