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Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats



Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats



American Journal of Physiology. Gastrointestinal and Liver Physiology 288(2): G277-G283



We examined the role of thromboxane A2 (TXA2) in LPS-induced hyperresponsiveness of hepatic portal circulation to endothelins (ETs) and whether Kupffer cells are the primary source of TXA2 release in response to ET-1 in endotoxemia. After 6 h of LPS (1 mg/kg body wt ip) or saline (control), liver was isolated and perfused with recirculating Krebs-Henseleit bicarbonate buffer at a constant flow rate (100 ml.min-1.kg body wt-1). ET-1 (10 pmol/min) was infused for 10 min.

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Accession: 012693529

Download citation: RISBibTeXText

PMID: 15647606

DOI: 10.1152/ajpgi.00256.2004


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