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Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer



Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer



Oncology Reports 14(3): 657-662



Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoro-pyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colorectal cancer who received one of two chemotherapy regimes (either irinotecan alone or irinotecan and 5-flurouracil with folinic acid).

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Accession: 012693706

Download citation: RISBibTeXText

PMID: 16077970

DOI: 10.3892/or.14.3.657


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