+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil



Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil



International Journal of Oncology 28(5): 1303-1310



Several variables associated to thymidylate synthase (TS), the biological target of 5-fluorouracil (5FU) have been studied for their possible role as predictors of the clinical outcome and response to chemotherapy in colorectal cancer (CRC) patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012693707

Download citation: RISBibTeXText

PMID: 16596248

DOI: 10.3892/ijo.28.5.1303


Related references

Prognostic value of thymidylate synthase (TS) expression on failure-free survival of fluorouracil-treated metastatic colorectal cancer patients. Journal of Clinical Oncology 24(18_suppl): 10011-10011, 2016

Thymidylate synthase expression pattern is a prognostic factor in patients of colorectal cancer treated with 5-fluorouracil. International Journal of Oncology 25(4): 877-885, 2004

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clinical Cancer Research 9(11): 4116-4124, 2003

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. British Journal of Cancer 85(6): 827-830, 2001

Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. International Journal of Cancer 112(5): 733-737, 2004

Thymidylate synthase quantitation predicts for disease-free survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Proceedings of the American Association for Cancer Research Annual Meeting 42: 618, March, 2001

DCC protein expression in colorectal cancer metastases and response to biochemically-modulated 5-fluorouracil in patients with low level of thymidylate synthase protein expression. International Journal of Cancer Supplement (13): 229, 2002

DCC protein expression in colorectal cancer metastases and lack of response to biochemically-modulated 5-fluorouracil among patients with low level of thymidylate synthase protein expression. EJC Supplements 1(5): S87, September, 2003

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil. Pharmacological Research 64(3): 242-248, 2011

Thymidylate synthase gene polymorphism and survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. Genetic Testing and Molecular Biomarkers 17(11): 799-806, 2014

Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer. Journal of Gastroenterology 40(2): 143-147, 2005

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. Annals of Oncology 19(5): 915-919, 2008

Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients. International Journal of Oncology 34(1): 219-229, 2009

Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer. Cancer ChemoTherapy and Pharmacology 61(4): 587-594, 2007

Intratumoral thymidylate synthase expression and response to 5-fluorouracil-leucovorin in patients with colorectal cancer. Proceedings of the American Association for Cancer Research Annual Meeting 34(0): 353, 1993