+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra



Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra



European Journal of Neuroscience 23(4): 1063-1070



The excitability of dopaminergic (DA) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the substantia nigra pars compacta, and VGLUT3 decorates a synapse population distinct from those marked by vesicular glutamate transporters 1 and 2. VGLUT3-ir nerve endings form asymmetric terminals on DA neurons. Retrograde tracing suggests the superior colliculus as an origin of excitatory VGLUT3-ir afferents. Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra.

(PDF emailed within 0-6 h: $19.90)

Accession: 012740897

Download citation: RISBibTeXText

PMID: 16519671

DOI: 10.1111/j.1460-9568.2006.04601.x


Related references

GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. European Journal of Neuroscience 19(3): 552-569, 2004

Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats. Neuro-Signals 15(5): 238-248, 2007

Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3). Journal of Chemical Neuroanatomy 38(4): 273-281, 2010

Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain. Neuroscience 123(4): 983-1002, 2004

Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain. Neuroscience Letters 464(3): 188-192, 2009

Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina. Brain Research 1215: 20-29, 2008

The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress. Journal of Physiology 590(20): 5183-5198, 2013

Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons. Frontiers in Neuroanatomy 10: 39-39, 2016

Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia. Neurobiology of Disease 87: 69-79, 2016

Nonserotonergic projection neurons in the midbrain raphe nuclei contain the vesicular glutamate transporter VGLUT3. Synapse 63(1): 31-41, 2008

VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. Journal of Neuroscience 30(6): 2198-2210, 2010

Role of the vesicular transporter VGLUT3 in retrograde release of glutamate by cerebellar Purkinje cells. Journal of Neurophysiology 105(3): 1023-1032, 2011

Differential expression of vesicular glutamate transporters by vagal afferent terminals in rat nucleus of the solitary tract: projections from the heart preferentially express vesicular glutamate transporter 1. Neuroscience 135(1): 133-145, 2005

Glutamate vesicular transporter bNPI and putative excitatory amino acid vesicular transporter dNPI show differential distribution in neurons projecting to cerebellar cortex in rat. Society for Neuroscience Abstracts 27(1): 1506, 2001

Evidence for a third vesicular glutamate transporter isoform vglut3 cloning,functional characterization and distribution in mouse brain. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 343 1, 2002