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WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action

WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action

Pigment Cell Research 18(3): 167-180

WNT1 and WNT3a have been described as having redundant roles in promoting the development of neural crest-derived melanocytes (NC-Ms). We used cell lineage restricted retroviral infections to examine the effects of WNT signaling on defined cell types in neural crest cultures. RCAS retroviral infections were targeted to melanoblasts (NC-M precursor cells) derived from transgenic mice that express the virus receptor, TVA, under the control of a melanoblast promoter (DCT).

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Accession: 012745584

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PMID: 15892713

DOI: 10.1111/j.1600-0749.2005.00226.x

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