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Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status



Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status



Cancer Research 65(1): 54-65



Androgen is critical for prostate development, growth, and survival. Therapies for advanced prostate cancer aim to block androgen receptor (AR) action. However, recurrent tumors ultimately arise, which harbor restored AR activity. One mechanism of such reactivation occurs through AR mutations, rendering the receptor responsive to noncanonical ligands.

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Accession: 012753133

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PMID: 15665279


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