PncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal
Portugal, I.; Barreiro, L.Ãs.; Moniz-Pereira, J.é; Brum, L.
Antimicrobial Agents and ChemoTherapy 48(7): 2736-2738
2004
ISSN/ISBN: 0066-4804 PMID: 15215139 DOI: 10.1128/aac.48.7.2736-2738.2004
Accession: 012759853
The nucleotide sequences of the pncA genes within 55 multidrug-resistant pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates were determined. Fifty-three out of the 55 isolates were pyrazinamidase (PZase) negative. Four strains contained a wild-type pncA gene, and PZase activity was undetectable in two of these strains. Seven of the 18 identified pncA mutations found have not been described in previous studies.
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