Section 13
Chapter 12,760

PncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal

Portugal, I.; Barreiro, L.ís.; Moniz-Pereira, J.é; Brum, L.

Antimicrobial Agents and ChemoTherapy 48(7): 2736-2738


ISSN/ISBN: 0066-4804
PMID: 15215139
DOI: 10.1128/aac.48.7.2736-2738.2004
Accession: 012759853

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The nucleotide sequences of the pncA genes within 55 multidrug-resistant pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates were determined. Fifty-three out of the 55 isolates were pyrazinamidase (PZase) negative. Four strains contained a wild-type pncA gene, and PZase activity was undetectable in two of these strains. Seven of the 18 identified pncA mutations found have not been described in previous studies.

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