Section 13
Chapter 12,777

Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia

Mand, S.; Supali, T.; Djuardi, J.; Kar, S.; Ravindran, B.; Hoerauf, A.

Tropical Medicine and International Health Tm and Ih 11(9): 1375-1381


ISSN/ISBN: 1360-2276
PMID: 16930259
DOI: 10.1111/j.1365-3156.2006.01693.x
Accession: 012776830

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In bancroftian filariasis, ultrasonography (USG) is a suitable tool to monitor infection by the detection of adult filariae in addition to antigen detection tests (ICT, Og4C3). However, in brugian filariasis, ultrasound examinations in humans have so far failed to detect adult worms and no antigen test is available to verify infections in patients who are carriers of adult worms but amicrofilaraemic. In this study, we describe the feasibility of detection of adult Brugia malayi filariae by USG. Worm nests were detected in 4 of 32 patients in India and Indonesia, located in the breast, the thigh, the calf and an inguinal lymph node. The study shows that adult filariae of B. malayi in humans can be detected by USG, but the technique is limited by the fact that worm nests seem not to be stable over time in humans, as is the case in bancroftian filariasis.

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