Section 13
Chapter 12,785

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis

Chiang, L.Y.; Ejzykowicz, D.E.; Tian, Z.-Q.; Katz, L.; Filler, S.G.

Antimicrobial Agents and ChemoTherapy 50(10): 3464-3466


ISSN/ISBN: 0066-4804
PMID: 17005833
DOI: 10.1128/aac.00558-06
Accession: 012784971

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Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

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