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Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis



Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis



Antimicrobial Agents and ChemoTherapy 50(10): 3464-3466



Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

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Accession: 012784971

Download citation: RISBibTeXText

PMID: 17005833

DOI: 10.1128/aac.00558-06


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