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Establishment of an immuno-suppressive mouse model of Pneumocystis pneumonia in Kunming strain of mice by using dexamethasone

Establishment of an immuno-suppressive mouse model of Pneumocystis pneumonia in Kunming strain of mice by using dexamethasone

Chinese Journal of Zoonoses 22(7): 668-670, 673

An experiment was conducted to establish an immunosuppressed mouse model of Pneumocystis pneumonia using dexamethasone. Kunming mice were given drinking water containing different doses of dexamethasone (2.5 mg/litre, 5 mg/litre and 7.5 mg/litre). The general condition, death rate, gross observation of lungs, detection rate of Pneumocystis cysts and trophozoites in lung sections were observed.

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