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Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF- beta -dependent pathways

Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF- beta -dependent pathways

Oncogene 24(42): 6345-6353

DNA damage normally induces p53 activity, but responses to ionizing radiation in the mammary epithelium vary among developmental stages. The following studies examined the hormones and growth factors that regulate radiation-responsiveness of p53 in mouse mammary epithelium. Immunoreactive p21/WAF1 and TUNEL staining were used as indicators of p53 activity following exposure to ionizing radiation.

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Accession: 012786706

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