+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Etiology of chronic diarrhea in antiretroviral-naive patients with HIV infection admitted to Norodom Sihanouk Hospital, Phnom Penh, Cambodia



Etiology of chronic diarrhea in antiretroviral-naive patients with HIV infection admitted to Norodom Sihanouk Hospital, Phnom Penh, Cambodia



Clinical Infectious Diseases 43(7): 925-932



Although both human immunodeficiency virus (HIV) infection and diarrhea are considerable problems in Cambodia, there have not been any studies to determine the history, clinical presentation, and etiology of chronic diarrhea in patients with HIV infection in Cambodia. In this article, we present a case-control study involving 40 HIV-infected patients with chronic diarrhea and 40 HIV-infected patients without diarrhea. Clinical, demographic, and laboratory data were collected. Stool samples were examined for parasites, including Cryptosporidium species (by partial acid-fast stain), bacterial pathogens, and rotavirus. Samples from 10 case patients and 10 control subjects were also analyzed for Cryptosporidium species by polymerase chain reaction-restriction fragment-length polymorphism. The median CD4(+) cell count was 11.5 cells/mm(3). A potential pathogen was found in 30 case patients (75%) and 29 control subjects (72.5%). Cryptosporidium was the most common pathogen, present in 16 case patients (40%) and 20 control subjects (53.3%). The presence of Cryptosporidium was confirmed by polymerase chain reaction-restriction fragment-length polymorphism, with a prevalence of 40% in each of the 2 groups of 10 subjects who were enrolled for Cryptosporidium evaluation. Subjects in this cohort had severe immunosuppression. The prevalence of pathogens, including Cryptosporidium, was extremely high but did not differ significantly between the case patients with diarrhea and the control subjects without diarrhea. Further studies are needed to examine factors associated with Cryptosporidium carriage and the natural history of asymptomatic infection.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 012786797

Download citation: RISBibTeXText

PMID: 16941378

DOI: 10.1086/507531


Related references

Toxoplasmosis in cambodia : initial serological evaluation at phnom penh changes in the resistance of plasmodium falciparum to chemical malaria treatments in cambodia from 1991 to 1997 clinical aspects of AIDS at calmette hospital, phnom penh knowledges, attitudes and practices of university students regarding HIV infection in phnom-penh, cambodia, 1999 cambodia and AIDS : french support tropical lung infections. Sante 9(6): 377-382, 2000

Prevalence and barriers to HIV testing among mothers at a tertiary care hospital in Phnom Penh, Cambodia. Barriers to HIV testing in Phnom Penh, Cambodia. Bmc Public Health 10: 494, 2010

High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at ESTHER/Calmette Hospital in Phnom Penh, Cambodia. Journal of the International Aids Society 14: 14, 2011

Aetiology of meningitis in HIV-infected patients in a referral hospital in Phnom Penh, Cambodia. International Journal of Std and Aids 15(1): 48-50, 2004

515Pcharacteristics of cancer patients registered at private hospital in Phnom Penh, Cambodia. Annals of Oncology 26(Suppl 9): ix158.2-ix158, 2015

Drug-resistant tuberculosis in HIV-infected patients in a national referral hospital, Phnom Penh, Cambodia. Global Health Action 8: 25964, 2015

A year of gunshot wounds at the CALMETTE Hospital of Phnom-Penh, Kingdom of Cambodia. Medecine Tropicale 54(4): 377, 1994

Anti-tuberculosis drug resistance and HIV co-infection in Phnom Penh, Cambodia. Southeast Asian Journal of Tropical Medicine and Public Health 40(1): 104-107, 2009

Some reflections on the surgery of gastric cancer in the principal hospital center of Phnom-Penh (Cambodia). Bordeaux Chirurgical 1: 37-39, 1965

Characteristics of liver cancer at Khmer-soviet Friendship Hospital in Phnom Penh, Cambodia. Asian Pacific Journal of Cancer Prevention 16(1): 35-39, 2015

Bloodstream infection among adults in Phnom Penh, Cambodia: key pathogens and resistance patterns. Plos one 8(3): E59775, 2013

Surveillance of bloodstream infection and antibiotic resistance in Phnom Penh, Cambodia (20072014). International Journal of Infectious Diseases 45: 110-111, 2016

Knowledge, attitudes and practices of university students regarding HIV infection, in Phnom Penh, Cambodia, 1999. Aids 13(14): 1982-1983, 1999

Reasons for routine episiotomy: A mixed-methods study in a large maternity hospital in Phnom Penh, Cambodia. Reproductive Health Matters 23(45): 68-77, 2015

Hospital-based surveillance for rotavirus diarrhoea in Phnom Penh, Cambodia, March 2005 through February 2007. Vaccine 27(Suppl. 5): F81-F84, 2009