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Key stages in mammary gland development - involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ



Key stages in mammary gland development - involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ



Breast Cancer Research 8(2): 203



Involution of the mammary gland is an essential process that removes the milk-producing epithelial cells when they become redundant at weaning. It is a two-step process that involves the death of the secretory epithelium and its replacement by adipocytes. During the first phase, remodelling is inhibited and apoptotic cells can be seen in the lumena of the alveoli. In the second phase, apoptosis is accompanied by remodelling of the surrounding stroma and re-differentiation of the adipocytes.

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Accession: 012800408

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DOI: 10.1186/bcr1401


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