Reproductive examination and histopathological findings of somatic cell-cloned Holstein Friesian cows with low reproductive and low lactational performance

Takahashi, M.; Tsuchiya, H.; Ueki, A.; Mita, N.; Kubo, M.; Goryo, M.; Hashizume, T.; Osawa, T.

Journal of the Japan Veterinary Medical Association 59(8): 540-543

2006


Accession: 012816137

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Abstract
Two somatic cell-cloned Holstein-Friesian cows (Cody 1 and Cody 2) diagnosed as having low reproductive or low lactational performance were examined. Although artificial insemination (AI) or embryo transfer (ET) was performed 15 times, Cody 1 became pregnant only twice, ultimately miscarrying. Given these results, the animal was euthanized at the age of 61 months. Cody 2 calved twice with a calving interval of 690 days. In both cows, GnRH analogue (fertirelin acetate, 100 micro g/head) was injected intramuscularly to test the ability of LH release from the pituitary, and the LH responses were similar to those of the two control cows. Macroscopically, the uterus in Cody 1 was discoloured and hypoplastic, and light microscopy disclosed that there were many calcareous deposits on the wall of some uterine arteries as well as an increased number of arteries in the endometrium. In Cody 2, milk composition was normal, whereas milk yields at the first (3897 kg/305 days) and secondary parity (6.312 kg/305 days) were much lower than those (average 11 015 kg/305 days) of the somatic cell donor cow. These results indicate the possibility that certain somatic cell-cloned cows may have low reproductive performance and low milk production.